Invention Grant
US07767678B2 Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile and methods of preparing the same
有权
4 - [（2,4-二氯-5-甲氧基苯基）氨基] -6-甲氧基-7- [3-（4-甲基-1-哌嗪基）丙氧基] -3-喹啉腈的结晶形式及其制备方法
![Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile and methods of preparing the same](/docs/US/2010-08-03/US07767678B2/abs.jpg.600x600.jpg)
- Patent Title: Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile and methods of preparing the same
- Patent Title (中): 4 - [（2,4-二氯-5-甲氧基苯基）氨基] -6-甲氧基-7- [3-（4-甲基-1-哌嗪基）丙氧基] -3-喹啉腈的结晶形式及其制备方法
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Application No.: US11478216Application Date: 2006-06-29
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Publication No.: US07767678B2Publication Date: 2010-08-03
- Inventor: Marc Sadler Tesconi , Gregg Feigelson , Henry Strong , Hong Wen
- Applicant: Marc Sadler Tesconi , Gregg Feigelson , Henry Strong , Hong Wen
- Applicant Address: US NJ Madison
- Assignee: Wyeth LLC
- Current Assignee: Wyeth LLC
- Current Assignee Address: US NJ Madison
- Agent David Rubin; Stephen D. Prodnuk
- Main IPC: A61K31/497
- IPC: A61K31/497 ; C07D241/04 ; C07D295/00
![Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile and methods of preparing the same](/abs-image/US/2010/08/03/US07767678B2/abs.jpg.150x150.jpg)
Abstract:
This invention is directed to a crystalline 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile monohydrate having an x-ray diffraction pattern wherein 2θ angles (°) of significant peaks are at about: 9.19, 11.48, 14.32, 19.16, 19.45, 20.46, 21.29, 22.33, 23.96, 24.95, 25.29, 25.84, 26.55, 27.61, and 29.51, and a transition temperature of about 109° C. to about 115° C.
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