Invention Grant
US07767687B2 Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
失效
吡啶并嘧啶酮，二氢嘧啶并嘧啶酮和可用作RAF激酶抑制剂的蝶啶酮
- Patent Title: Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
- Patent Title (中): 吡啶并嘧啶酮，二氢嘧啶并嘧啶酮和可用作RAF激酶抑制剂的蝶啶酮
-
Application No.: US11301311Application Date: 2005-12-12
-
Publication No.: US07767687B2Publication Date: 2010-08-03
- Inventor: Johan D. Oslob , Jiang Zhu , Kenneth Barr , Jennifer Cossrow , Brian Raimundo , Hiroko Tanaka
- Applicant: Johan D. Oslob , Jiang Zhu , Kenneth Barr , Jennifer Cossrow , Brian Raimundo , Hiroko Tanaka
- Applicant Address: US MA Cambridge US CA South San Francisco
- Assignee: Biogen Idec MA Inc.,Sunesis Pharmaceuticals, Inc.
- Current Assignee: Biogen Idec MA Inc.,Sunesis Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge US CA South San Francisco
- Agency: Choate, Hall & Stewart LLP
- Agent Andrea L. C. Robidoux; Emilie Porter Huck
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D487/04 ; C07D473/40 ; C07D473/00 ; A61K31/519 ; C07D475/00
Abstract:
The present invention provides compounds having the formula: wherein A-B together represent one of the following structures: n, R1, R2, R3, R4, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.
Public/Granted literature
- US20060211702A1 Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as Raf kinase inhibitors Public/Granted day:2006-09-21
Information query
