发明授权
US07767687B2 Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
失效
吡啶并嘧啶酮，二氢嘧啶并嘧啶酮和可用作RAF激酶抑制剂的蝶啶酮
- 专利标题： Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
- 专利标题（中）： 吡啶并嘧啶酮，二氢嘧啶并嘧啶酮和可用作RAF激酶抑制剂的蝶啶酮
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申请号： US11301311申请日： 2005-12-12
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公开(公告)号： US07767687B2公开(公告)日： 2010-08-03
- 发明人: Johan D. Oslob , Jiang Zhu , Kenneth Barr , Jennifer Cossrow , Brian Raimundo , Hiroko Tanaka
- 申请人： Johan D. Oslob , Jiang Zhu , Kenneth Barr , Jennifer Cossrow , Brian Raimundo , Hiroko Tanaka
- 申请人地址： US MA Cambridge US CA South San Francisco
- 专利权人： Biogen Idec MA Inc.,Sunesis Pharmaceuticals, Inc.
- 当前专利权人： Biogen Idec MA Inc.,Sunesis Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge US CA South San Francisco
- 代理机构： Choate, Hall & Stewart LLP
- 代理商 Andrea L. C. Robidoux; Emilie Porter Huck
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D487/04 ; C07D473/40 ; C07D473/00 ; A61K31/519 ; C07D475/00
摘要：
The present invention provides compounds having the formula: wherein A-B together represent one of the following structures: n, R1, R2, R3, R4, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.
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