Invention Grant
US07767803B2 Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
失效
PSMA的稳定适体及其作为前列腺癌治疗剂的用途
- Patent Title: Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
- Patent Title (中): PSMA的稳定适体及其作为前列腺癌治疗剂的用途
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Application No.: US11370491Application Date: 2006-03-07
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Publication No.: US07767803B2Publication Date: 2010-08-03
- Inventor: John L. Diener , Paul Hatala , Jess Wagner-Whyte , Charles Wilson
- Applicant: John L. Diener , Paul Hatala , Jess Wagner-Whyte , Charles Wilson
- Applicant Address: US MA Cambridge
- Assignee: Archemix Corp.
- Current Assignee: Archemix Corp.
- Current Assignee Address: US MA Cambridge
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo P.C.
- Agent Ivor R. Elrifi
- Main IPC: A61K21/00
- IPC: A61K21/00
Abstract:
The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2′-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.
Public/Granted literature
- US20070041901A1 Stabilized aptamers to PSMA and their use as prostate cancer therapeutics Public/Granted day:2007-02-22
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