Invention Grant
- Patent Title: Fused tricyclic mGluR1 antagonists as therapeutic agents
- Patent Title (中): 融合的三环mGluR1拮抗剂作为治疗剂
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Application No.: US11504860Application Date: 2006-08-16
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Publication No.: US07767815B2Publication Date: 2010-08-03
- Inventor: Chad E. Bennett , Wen-Lian Wu , Duane A. Burnett
- Applicant: Chad E. Bennett , Wen-Lian Wu , Duane A. Burnett
- Applicant Address: US NJ Kenilworth
- Assignee: Schering Corporation
- Current Assignee: Schering Corporation
- Current Assignee Address: US NJ Kenilworth
- Agent Kenrick L. Vidale; John C. Todaro; Keith D. MacMillan
- Main IPC: C07D409/14
- IPC: C07D409/14 ; A61K31/4365
Abstract:
In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J3, X, Z, and R1-R4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.
Public/Granted literature
- US20070072863A1 Fused tricyclic mGluR1 antagonists as therapeutic agents Public/Granted day:2007-03-29
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