Invention Grant
- Patent Title: Process for the preparation of chirally pure N-(trans-4-is)
- Patent Title (中): 手性纯N-（反式-4-异构体）的制备方法
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Application No.: US10564017Application Date: 2004-07-08
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Publication No.: US07767847B2Publication Date: 2010-08-03
- Inventor: Maria Gazdag , Tibor Gizur , Bela Hegedus , Attila Szemzo , Gabor Tarkanyi , Jozsef Törley , Monika Babjak
- Applicant: Maria Gazdag , Tibor Gizur , Bela Hegedus , Attila Szemzo , Gabor Tarkanyi , Jozsef Törley , Monika Babjak
- Applicant Address: HU Budapest
- Assignee: Richter Gedeon Vegyeszeti Gyar RT.
- Current Assignee: Richter Gedeon Vegyeszeti Gyar RT.
- Current Assignee Address: HU Budapest
- Agent Jonathan Myers; Andrew Wilford
- Priority: HUP0302174 20030710
- International Application: PCT/HU2004/000073 WO 20040708
- International Announcement: WO2005/005373 WO 20050120
- Main IPC: C07C229/00
- IPC: C07C229/00
Abstract:
The invention relates to N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine (nateglinide) in the novel crystalline form “G” and a process for the preparation thereof. A process for the preparation of chirally pure nateglinide by treating a lower alkyl ester thereof with a base to yield an alkali salt and liberating the product from said salt by proper addition of an acid, is also provided. Still another aspect of the invention is a process for the preparation of nateglinide in the crystalline form “H” from other crystalline modifications of nateglinide.
Public/Granted literature
- US20070043117A1 Process for the preparation of chirally pure n-(trans-4-is Public/Granted day:2007-02-22
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