The present invention is to provide an apparatus and method for calibrating focus balance in an optical disk drive. A focus servo unit controls a pick-up head to focus and read a mark for generating an RF signal. A jitter generator separates a jitter signal from the RF signal to form a jitter frequency. A focus balance unit compares sequential jitter frequencies to check the convergence and the goal, and determines the direction and variable of calibrating focus balance to generate an error signal. A compensator receives the error signal through the focus servo unit to control the pick-up head for calibrating focus balance.