Facilitating viewer comparison of a plurality of medical images of at least one body part on a softcopy review workstation is described. First and second medical images are displayed such that the second medical image appears as a spatially registered underlay to the first medical image exposed through an aperture therein. The aperture comprises at least one edge that is viewer-manipulable in a back-and-forth manner so that the first and second medical images can be visually compared with minimal eye movement. For a temporal comparison embodiment, the first and second medical images comprise identical views of the same body part acquired at different times. For a cross-modality comparison embodiment, the first and second medical images are acquired substantially concurrently, or at different times, using different medical imaging modalities. For a bilateral comparison embodiment, the first and second images are corresponding views of two laterally corresponding body parts.