Invention Grant
US07769423B2 MRI imageable liposomes for the evaluation of treatment efficacy, thermal distribution, and demonstration of dose painting
失效
MRI可成像的脂质体用于评估治疗效果，热分布和剂量绘画的演示
- Patent Title: MRI imageable liposomes for the evaluation of treatment efficacy, thermal distribution, and demonstration of dose painting
- Patent Title (中): MRI可成像的脂质体用于评估治疗效果，热分布和剂量绘画的演示
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Application No.: US11648148Application Date: 2006-12-29
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Publication No.: US07769423B2Publication Date: 2010-08-03
- Inventor: Benjamin L. Viglianti , Mark W. Dewhirst , Ana M. Ponce
- Applicant: Benjamin L. Viglianti , Mark W. Dewhirst , Ana M. Ponce
- Applicant Address: US NC Durham
- Assignee: Duke University
- Current Assignee: Duke University
- Current Assignee Address: US NC Durham
- Agency: Jenkins, Wilson, Taylor & Hunt, P.A.
- Main IPC: A61B5/05
- IPC: A61B5/05
Abstract:
Methods and compositions useful for detecting an in vivo blood pool, monitoring the distribution of a compound of interest to a desired site in an organism by magnetic resonance imaging, monitoring the accumulation of a compound of interest at a desired site in vivo by magnetic resonance imaging, and monitoring the release of liposomal contents to an external stimulus at a desired site in vivo by magnetic resonance imaging are disclosed. Some compositions comprise envirosensitive or non-sensitive liposomes. Contrast agents, such as manganese-based compounds, are also disclosed.
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