A message notice reply system and a method thereof are disclosed. A message reply scheme functioning a deadline, address and verification for replying is introduced into an electronic mail system. As a sender transmits the message, a message-to-reply field will be incorporated to the message, and a reply field will be added after the recipient opens it. More, a reminder, which can be configured to send to a mobile phone or telephone via VoIP connection, will be launched before the deadline. The reply field won't be checked until the recipient replies the message. As well, the message-to-reply field won't be checked until the sender receives the reply. Further, a multimedia apparatus and a handwriting device are utilized to transmit a multimedia message from the sender and reply from the recipient. The invention is applied to substitute the conventional appointment between people that can not trace the schedule precisely.