发明授权
- 专利标题: Imidazo[1,2-b]pyridazine compound
- 专利标题(中): 咪唑并[1,2-b]哒嗪化合物
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申请号: US12397132申请日: 2009-03-03
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公开(公告)号: US07772249B2公开(公告)日: 2010-08-10
- 发明人: Shigeki Hibi , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
- 申请人: Shigeki Hibi , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
- 申请人地址: JP Bunkyo-Ku, Tokyo
- 专利权人: Eisai R&D Management Co., Ltd.
- 当前专利权人: Eisai R&D Management Co., Ltd.
- 当前专利权人地址: JP Bunkyo-Ku, Tokyo
- 代理机构: Birch, Stewart, Kolasch & Birch, LLP
- 优先权: JP2001-032637 20010208; JP2001-133208 20010427
- 主分类号: A61K31/44
- IPC分类号: A61K31/44
摘要:
The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R1 denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R2 denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R3 denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR4 (wherein R4 denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR4.
公开/授权文献
- US20090181985A1 IMIDAZO[1,2-b]PYRIDAZINE COMPOUND 公开/授权日:2009-07-16
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