Invention Grant
US07772430B2 Derivatives of arylsulfonamido-substituted hydroxamic acid as matrix metalloproteinases inhibitors
失效
芳基磺酰氨基取代的异羟肟酸作为基质金属蛋白酶抑制剂的衍生物
- Patent Title: Derivatives of arylsulfonamido-substituted hydroxamic acid as matrix metalloproteinases inhibitors
- Patent Title (中): 芳基磺酰氨基取代的异羟肟酸作为基质金属蛋白酶抑制剂的衍生物
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Application No.: US11659431Application Date: 2005-07-29
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Publication No.: US07772430B2Publication Date: 2010-08-10
- Inventor: Ivano Bertini , Marco Fragai , Mauro Lo Conte , Claudio Luchinat , Cristina Nativi , Chiara Venturi
- Applicant: Ivano Bertini , Marco Fragai , Mauro Lo Conte , Claudio Luchinat , Cristina Nativi , Chiara Venturi
- Applicant Address: IT Sesto Fiorentino
- Assignee: Protera S.R.L.
- Current Assignee: Protera S.R.L.
- Current Assignee Address: IT Sesto Fiorentino
- Agency: Abelman, Frayne & Schwab
- Priority: ITFI2004A0174 20040803
- International Application: PCT/EP2005/053722 WO 20050729
- International Announcement: WO2006/013193 WO 20060209
- Main IPC: C07C303/00
- IPC: C07C303/00 ; C07C307/00 ; C07C309/00 ; C07C311/00 ; A01N41/06 ; A61K31/18 ; A61K31/70 ; A01N43/04 ; C07H15/00 ; C07H17/00 ; C07H17/02
Abstract:
Described herein are derivatives of arylsulfonamido-substituted hydroxamic acid of formula (I) having good solubility in water and inhibitory activity of matrix metalloproteinases, useful for the preparation of pharmaceutical compositions for the treatment of diseases associated to a pathologic activity and/or an over-expression of metalloproteinases, and of cosmetic preparations having anti-ageing properties in particular for hair and skin.
Public/Granted literature
- US20080249032A1 Derivatives of Arylsulfonamido-Substituted Hydroxamic Acid as Matrix Metalloproteinases Inhibitors Public/Granted day:2008-10-09
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