发明授权
US07776859B2 Hexahydroimidazopyrazin-3-one compounds useful as modulators of androgen receptor function
有权
六氢咪唑并吡嗪-3-酮化合物可用作雄激素受体功能的调节剂
- 专利标题: Hexahydroimidazopyrazin-3-one compounds useful as modulators of androgen receptor function
- 专利标题(中): 六氢咪唑并吡嗪-3-酮化合物可用作雄激素受体功能的调节剂
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申请号: US11546965申请日: 2006-10-12
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公开(公告)号: US07776859B2公开(公告)日: 2010-08-17
- 发明人: James Aaron Balog , Mark E. Salvati , Brian E. Fink
- 申请人: James Aaron Balog , Mark E. Salvati , Brian E. Fink
- 申请人地址: US NJ Princeton
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 当前专利权人地址: US NJ Princeton
- 代理商 Gary D. Greenblatt; Anastasia P. Winslow
- 主分类号: A61K31/4985
- IPC分类号: A61K31/4985
摘要:
The present invention is directed to compounds having the formula (I), and/or pharmaceutically-acceptable salts thereof, useful in the treatment of androgen-receptor associated conditions, wherein Ar is aryl, substituted aryl, heteroaryl, or substituted heteroaryl; L is a linker as defined in the specification; R1 may be hydrogen, cyano, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclo, substituted heterocyclo, heteroaryl, or substituted heteroaryl, as defined in the specification; R2 is hydrogen, lower alkyl, or substituted lower alkyl; and R3, R4 and R5 are optionally non-interfering substituents as defined in the specification.
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