发明授权
- 专利标题： VLA-4 antagonists
- 专利标题（中）： VLA-4拮抗剂
-
申请号： US11659608申请日： 2005-08-12
-
公开(公告)号： US07776891B2公开(公告)日： 2010-08-17
- 发明人: Weichao Chen , Alec D. Lebsack , Benito Munoz , Shankar Venkatraman , Bowei Wang
- 申请人： Weichao Chen , Alec D. Lebsack , Benito Munoz , Shankar Venkatraman , Bowei Wang
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Mollie M. Yang; Valerie J. Camara
- 国际申请： PCT/US2005/028768 WO 20050812
- 国际公布： WO02/074761 WO 20020926
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; C07D401/02
摘要：
Compounds of Formula (I) are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of inflammatory bowel disease including ulcerative colitis and Crohn's disease, multiple sclerosis, asthma, and rheumatoid arthritis.
公开/授权文献
- US20070219252A1 Vla-R Antagonists 公开/授权日：2007-09-20