发明授权
US07776894B2 Compositions and methods for inhibiting growth and metastasis of melanoma
有权
抑制黑色素瘤生长和转移的组合物和方法
- 专利标题： Compositions and methods for inhibiting growth and metastasis of melanoma
- 专利标题（中）： 抑制黑色素瘤生长和转移的组合物和方法
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申请号： US12192753申请日： 2008-08-15
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公开(公告)号： US07776894B2公开(公告)日： 2010-08-17
- 发明人: Ze'ev A. Ronai , Anindita Bhoumik , Nicholas D. P. Cosford , Russell Dahl
- 申请人： Ze'ev A. Ronai , Anindita Bhoumik , Nicholas D. P. Cosford , Russell Dahl
- 申请人地址： US CA La Jolla
- 专利权人： Burnham Institute for Medical Research
- 当前专利权人： Burnham Institute for Medical Research
- 当前专利权人地址： US CA La Jolla
- 代理机构： DLA Piper LLP (US)
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/4406 ; A61K31/215 ; A61K31/165 ; A61K31/16
摘要：
There are provided methods of inhibiting growth and metastasis of melanoma, methods of sensitizing melanoma cells to apoptosis, and methods of treating a subject having melanoma using acetyl isogambogic acid, celastrol, or a derivative thereof. There are further provided derivatives of celastrol and compositions comprising acetyl isogambogic acid, celastrol, or a derivative thereof.
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