发明授权
US07776904B2 Azabicyclo [3.1.0] hexylphenyl derivatives as modulators of dopamine D3 receptors
失效
氮杂双环[3.1.0]己基苯基衍生物作为多巴胺D3受体的调节剂
- 专利标题: Azabicyclo [3.1.0] hexylphenyl derivatives as modulators of dopamine D3 receptors
- 专利标题(中): 氮杂双环[3.1.0]己基苯基衍生物作为多巴胺D3受体的调节剂
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申请号: US12064121申请日: 2006-08-18
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公开(公告)号: US07776904B2公开(公告)日: 2010-08-17
- 发明人: Gabriella Gentile , Dieter Hamprecht , Fabrizio Micheli , Adolfo Prandi , Silvia Terreni
- 申请人: Gabriella Gentile , Dieter Hamprecht , Fabrizio Micheli , Adolfo Prandi , Silvia Terreni
- 申请人地址: GB Brentford, Middlesex
- 专利权人: Glaxo Group Limited
- 当前专利权人: Glaxo Group Limited
- 当前专利权人地址: GB Brentford, Middlesex
- 代理商 James M. Kanagy; Edward R. Gimmi; Charles M. Kinzig
- 优先权: GB0517175.6 20050822
- 国际申请: PCT/EP2006/008202 WO 20060818
- 国际公布: WO2007/022935 WO 20070301
- 主分类号: A61K31/403
- IPC分类号: A61K31/403 ; C07D209/52
摘要:
The present invention relates to novel compounds of formula (IA) or a salt thereof: wherein: A is attached to the phenyl group at the meta position or the para position relative to the cyclopropyl group, and is selected from the group consisting of: —SO2NR5—, —SO2CR2R3—, —CR2R3SO2— and —NR5SO2—; R1 is hydrogen, C1-6alkyl, haloC1-6alkyl or C2-6alkylene; R2 and R3 are independently hydrogen or C1-6alkyl; R4 is hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, C1-6alkoxy or haloC1-6alkoxy; R5 is hydrogen, C1-6alkyl, or a phenyl optionally substituted by R4; and R6 is hydrogen, C1-6alkyl, haloC1-6alkyl, C1-6alkoxy or haloC1-6alkoxy; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat substance related disorders, as antipsychotic agents premature ejaculation or cognition impairment.
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