发明授权
US07777018B2 CDR-grafted anti-tissue factor antibodies and methods of use thereof
有权
CDR移植的抗组织因子抗体及其使用方法
- 专利标题： CDR-grafted anti-tissue factor antibodies and methods of use thereof
- 专利标题（中）： CDR移植的抗组织因子抗体及其使用方法
-
申请号： US11926684申请日： 2007-10-29
-
公开(公告)号： US07777018B2公开(公告)日： 2010-08-17
- 发明人: Linda K. Joliffe , Robert A. Zivin , Virginia L. Pulito
- 申请人： Linda K. Joliffe , Robert A. Zivin , Virginia L. Pulito
- 申请人地址： US PA Malvern
- 专利权人： Centocor, Inc.
- 当前专利权人： Centocor, Inc.
- 当前专利权人地址： US PA Malvern
- 代理商 Kenneth J. Dow
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12P21/08
摘要：
The present invention provides CDR-grated antibodies against human tissue factor that retain the high binding affinity of rodent monoclonal antibodies against tissue factor but have reduced immunogenicity. The present humanized antibodies are potent anticoagulants and are thus useful in the treatment and prophylaxis of human thrombotic disease. The invention also provides methods of making the CFR-grafted antibodies and pharmaceutical compositions for the attenuation or prevention of coagulation.