发明授权
- 专利标题: Production of carnitine conjugate intermediates
- 专利标题(中): 生产肉碱共轭中间体
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申请号: US11660299申请日: 2006-08-11
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公开(公告)号: US07777071B2公开(公告)日: 2010-08-17
- 发明人: Om P Goel
- 申请人: Om P Goel
- 申请人地址: US MI Ann Arbor
- 专利权人: SSV Therapeutics, Inc.
- 当前专利权人: SSV Therapeutics, Inc.
- 当前专利权人地址: US MI Ann Arbor
- 代理机构: Technology Law PLLC
- 代理商 Karen L. Kimble
- 国际申请: PCT/US2006/031362 WO 20060811
- 国际公布: WO2008/018877 WO 20080214
- 主分类号: C07C69/74
- IPC分类号: C07C69/74
摘要:
The present invention discloses novel dual prodrug compounds of formula (1), methods for their preparation and intermediates in their syntheses, formula (1): wherein A is a single bond, —O—, or —CH2—; m and n vary independently and are an integer from 1 to 15; p and q vary from 0 to an integer from 1 to 4; B is a single bond or —CR3R4; D is formula (2): or formula (3): and X is halogen; R1 to R4 are various substituents selected to optimize the physiochemical and biological properties such as, lipophilicity, bioavailability, and pharmacokinetics of compounds of Formula 1; and R1 and R2 or R3 and R4 may optionally be tethered together to form a 3- to 7-membered alicyclic ring. These compounds are useful for the treatment of various infections, metabolic, cardiovascular and neurological disorders.
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