A reconfigurable multi-processor computing system including a plurality of configurable processing elements each having a plurality of integrated high-speed serial input/output ports. Interconnects link the plurality of processing elements, wherein at least one of the integrated high-speed serial input/output ports of each processing element is connected by at least one interconnect to at least one of the integrated high-speed serial input/output ports of each other processing element, thereby creating a full mesh network. The full mesh network is located on a processor card, multiples of which may be grouped in a shelf having a backplane card with a shelf controller card for providing cross-connects between processor cards. Multiple shelves may be interconnected to form a large computer system.