发明授权
US07781416B2 Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
有权
部分脱硫的糖胺聚糖衍生物作为乙酰肝素酶抑制剂，具有抗血管生成活性，无抗凝作用
- 专利标题： Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
- 专利标题（中）： 部分脱硫的糖胺聚糖衍生物作为乙酰肝素酶抑制剂，具有抗血管生成活性，无抗凝作用
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申请号： US11314736申请日： 2005-12-22
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公开(公告)号： US07781416B2公开(公告)日： 2010-08-24
- 发明人: Benito Casu , Giangiacomo Torri , Anna Maria Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
- 申请人： Benito Casu , Giangiacomo Torri , Anna Maria Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
- 申请人地址： CH Lugano
- 专利权人： Sigma-Tau Research Switzerland S.A.
- 当前专利权人： Sigma-Tau Research Switzerland S.A.
- 当前专利权人地址： CH Lugano
- 代理机构： Lucas & Mercanti, LLP
- 主分类号： A61K31/727
- IPC分类号： A61K31/727 ; A61K31/737
摘要：
Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
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