Disclosed are systems and methods of eliminating or reducing interference resulting from harmonics of local oscillator frequencies of mixers. In one embodiment, a determination is made as to a zone or zones in which harmonics result in undesired spur generation. Inter-tuner spurs and intra-tuner spurs may be identified such that frequency information of the identified spurs may be utilized to define a plurality of exclusion zones. LO frequencies may subsequently be efficiently selected in view of the exclusion zone information. Embodiments may also determine a score for identified spurs which may be used to optimally select from within a set of spur-generating local oscillator frequencies.