发明授权
- 专利标题: Silyl linker for solid-phase synthesis of nucleic acid
- 专利标题(中): 用于固相合成核酸的硅烷基接头
-
申请号: US10590267申请日: 2005-02-10
-
公开(公告)号: US07786296B2公开(公告)日: 2010-08-31
- 发明人: Mitsuo Sekine , Kohji Seio , Akihiro Ohkubo
- 申请人: Mitsuo Sekine , Kohji Seio , Akihiro Ohkubo
- 申请人地址: JP Kawaguchi-shi Saitama
- 专利权人: Japan Science and Technology Agency
- 当前专利权人: Japan Science and Technology Agency
- 当前专利权人地址: JP Kawaguchi-shi Saitama
- 代理机构: Birch, Stewart, Kolasch & Birch, LLP.
- 优先权: JP2004-049303 20040225
- 国际申请: PCT/JP2005/002059 WO 20050210
- 国际公布: WO2005/080404 WO 20050901
- 主分类号: C07H19/00
- IPC分类号: C07H19/00 ; C07H19/048
摘要:
The purpose of the invention is to develop a silyl linker that can be efficiently introduced on a solid-phase support used for the synthesis of nucleic acid oligomers such as DNA. The present invention relates to a silyl linker for use in the solid-phase synthesis of nucleic acid, comprised of a compound of the general formula or its ester or salt: H—(R1)Si(R2)-(C6H4)—CONH-(A)-COOH (I) wherein each of R1 and R2 is an alkyl or aryl group, and (A) represents a spacer moiety; a 3′-end nucleoside unit having said compound linked via an oxygen atom to the 3-position of a sugar of the nucleoside or its derivative, a solid-phase support having the 3′-end nucleoside unit, and a method for synthesis of nucleic acid oligomer with the use of said solid-phase support.
公开/授权文献
- US20080051571A1 Silyl Linker For Solid-Phase Synthesis Of Nucleic Acid 公开/授权日:2008-02-28
信息查询