发明授权
US07790722B2 Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
失效
吲哚，1H-吲唑，1,2-苯并异恶唑和1,2-苯并异噻唑，及其制备和用途
- 专利标题： Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
- 专利标题（中）： 吲哚，1H-吲唑，1,2-苯并异恶唑和1,2-苯并异噻唑，及其制备和用途
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申请号： US12128839申请日： 2008-05-29
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公开(公告)号： US07790722B2公开(公告)日： 2010-09-07
- 发明人: Wenge Xie , Brian Herbert , Jianguo Ma , Truc Minh Nguyen , Richard Schumacher , Carla Maria Gauss , Ashok Tehim
- 申请人： Wenge Xie , Brian Herbert , Jianguo Ma , Truc Minh Nguyen , Richard Schumacher , Carla Maria Gauss , Ashok Tehim
- 申请人地址： US NJ Montvale
- 专利权人： Memory Pharmaceuticals Corporation
- 当前专利权人： Memory Pharmaceuticals Corporation
- 当前专利权人地址： US NJ Montvale
- 代理机构： Millen, White, Zelano, Branigan, P.C.
- 主分类号： A61K31/4995
- IPC分类号： A61K31/4995 ; A61K31/425 ; A61K31/42 ; C07D241/36 ; C07D275/04 ; C07D261/20
摘要：
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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