发明授权
- 专利标题： Process for production of optically active PPAR-activating compound and intermediate of the same
- 专利标题（中）： 光学活性PPAR活化化合物及其中间体的制备方法
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申请号： US11816472申请日： 2006-02-23
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公开(公告)号： US07790903B2公开(公告)日： 2010-09-07
- 发明人: Yukiyoshi Yamazaki , Takaaki Araki , Minoru Koura , Kimiyuki Shibuya
- 申请人： Yukiyoshi Yamazaki , Takaaki Araki , Minoru Koura , Kimiyuki Shibuya
- 申请人地址： JP Nagoya-shi
- 专利权人： Kowa Co., Ltd.
- 当前专利权人： Kowa Co., Ltd.
- 当前专利权人地址： JP Nagoya-shi
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 优先权： JP2005-047476 20050223
- 国际申请： PCT/JP2006/303245 WO 20060223
- 国际公布： WO2006/090768 WO 20060831
- 主分类号： C07D263/58
- IPC分类号： C07D263/58
摘要：
A process for obtaining a compound (1) and an intermediate thereof in high yield and high optical yield is provided.A process for producing a compound (4), the process including reacting a compound (2) with a compound (3) in the presence of a base; and a process for producing a compound (1), the process including reacting a compound (2) with a compound (3) in the presence of a base to yield a compound (4) and then deesterifying the compound (4). wherein R represents an alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 8 carbon atoms.
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