发明授权
US07794952B2 Biomarker isolation and use thereof to characterize physiological state
有权
生物标志物分离及其用于表征生理状态
- 专利标题： Biomarker isolation and use thereof to characterize physiological state
- 专利标题（中）： 生物标志物分离及其用于表征生理状态
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申请号： US11639414申请日： 2006-12-15
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公开(公告)号： US07794952B2公开(公告)日： 2010-09-14
- 发明人: Lance Liotta , Emanuel Petricoin
- 申请人： Lance Liotta , Emanuel Petricoin
- 申请人地址： US VA Fairfax
- 专利权人： George Mason University
- 当前专利权人： George Mason University
- 当前专利权人地址： US VA Fairfax
- 代理机构： Millen, White, Zelano, Branigan, P.C.
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
The present invention relates to compositions and methods for characterizing the physiological state of a living system, including cells, tissues, organs, and whole organisms. The methods involve capturing biomarkers from the living system, and correlating their presence or absence to a physiological state. The biomarkers can be captured from the system, and then detected using any suitable analytical system to determine their presence or absence. In one embodiment, the invention relates to a method of detecting a polypeptide biomarker in a blood serum or plasma sample obtained from a single subject with an affinity ligand which is capable of binding to a plurality of different polypeptide biomarkers derived from the same parental molecule.
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