发明授权
US07795278B2 Substituted tetrahydro-2H-isoquinolin-1-one derivatives, and methods for the production and use thereof
失效
取代的四氢-2H-异喹啉-1-酮衍生物及其制备和使用方法
- 专利标题： Substituted tetrahydro-2H-isoquinolin-1-one derivatives, and methods for the production and use thereof
- 专利标题（中）： 取代的四氢-2H-异喹啉-1-酮衍生物及其制备和使用方法
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申请号： US11567352申请日： 2006-12-06
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公开(公告)号： US07795278B2公开(公告)日： 2010-09-14
- 发明人: Stefan Peukert , Stefan Guessregen , Armin Hofmeister , Herman Schreuder , Uwe Schwahn
- 申请人： Stefan Peukert , Stefan Guessregen , Armin Hofmeister , Herman Schreuder , Uwe Schwahn
- 申请人地址： US DE Frankfurt am Main
- 专利权人： sanofi-aventis Deutschland GmbH
- 当前专利权人： sanofi-aventis Deutschland GmbH
- 当前专利权人地址： US DE Frankfurt am Main
- 代理商 Serena Farquharson-Torres
- 优先权： DE102004028973 20040616
- 主分类号： C07D217/22
- IPC分类号： C07D217/22 ; A61K31/47
摘要：
This invention relates to compounds according to the general formula (I), where the definitions of the substituents R1, R2, Ar and X are as specified in the description, and to their physiologically tolerated salts, methods for the preparation of these compounds and their use as medicaments. These compounds are poly(ADP-ribose) polymerase (PARP) inhibitors.