发明授权
US07799787B2 Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
失效
杂芳族化合物作为硬脂酰辅酶A-9去饱和酶的抑制剂
- 专利标题： Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
- 专利标题（中）： 杂芳族化合物作为硬脂酰辅酶A-9去饱和酶的抑制剂
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申请号： US12086023申请日： 2006-12-18
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公开(公告)号： US07799787B2公开(公告)日： 2010-09-21
- 发明人: Denis Deschenes , Rejean Fortin , Chun Sing Li , Renata M. Oballa , Yeeman K. Ramtohul
- 申请人： Denis Deschenes , Rejean Fortin , Chun Sing Li , Renata M. Oballa , Yeeman K. Ramtohul
- 申请人地址： CA Quebec
- 专利权人： Merck Frosst Canada Ltd.
- 当前专利权人： Merck Frosst Canada Ltd.
- 当前专利权人地址： CA Quebec
- 代理商 Philippe L. Durette; John C. Todaro
- 国际申请： PCT/CA2006/002053 WO 20061218
- 国际公布： WO2007/071023 WO 20070628
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; A61K31/501 ; A61P9/00 ; A61P9/10 ; A61P35/00 ; A61P3/10 ; A61P3/04 ; A61P3/00 ; A61P1/16
摘要：
Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; fatty liver disease and cancer.