发明授权
- 专利标题： Synthesis and use of 2′-substituted-N6 -modified nucleosides
- 专利标题（中）： 2'-取代-N6修饰核苷的合成与应用
-
申请号： US10542235申请日： 2004-01-15
-
公开(公告)号： US07799908B2公开(公告)日： 2010-09-21
- 发明人: Haoyun An , Kanda Ramasamy , Stephanie Shaw
- 申请人： Haoyun An , Kanda Ramasamy , Stephanie Shaw
- 申请人地址： US CA Aliso Viejo
- 专利权人： Valeant Pharmaceuticals North America
- 当前专利权人： Valeant Pharmaceuticals North America
- 当前专利权人地址： US CA Aliso Viejo
- 代理机构： McDermott Will & Emery LLP
- 国际申请： PCT/US2004/001125 WO 20040115
- 国际公布： WO2004/065398 WO 20040805
- 主分类号： C07H19/167
- IPC分类号： C07H19/167 ; C07H19/173
摘要：
An improved method of preparing a sugar modified nucleoside analog includes a protocol in which a hydroxy group of a sugar is selectively deprotected and oxidized prior to nucleophilic modification of the corresponding carbonyl group. The modified sugar is then coupled to a heterocyclic base that is modified with a dual nucleophilic reagent in a further step that provides N6-modified adenosine analogs with high stereoselectivity.