发明授权
US07799913B2 Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses
失效
羰基苯并恶嗪化合物用于增强谷氨酸能突触应答
- 专利标题： Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses
- 专利标题（中）： 羰基苯并恶嗪化合物用于增强谷氨酸能突触应答
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申请号： US10495049申请日： 2002-11-25
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公开(公告)号： US07799913B2公开(公告)日： 2010-09-21
- 发明人: Gary A. Rogers , Matthew Allan , Clayton Harris , Jianjie Huang , Christopher M. Marrs , Rudolf Mueller , Stanislaw Rachwal
- 申请人： Gary A. Rogers , Matthew Allan , Clayton Harris , Jianjie Huang , Christopher M. Marrs , Rudolf Mueller , Stanislaw Rachwal
- 申请人地址： US CA Irvine
- 专利权人： Cortex Pharmaceuticals, Inc.
- 当前专利权人： Cortex Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Irvine
- 代理商 Henry D. Coleman; R. Neil Sudol; William J. Sapone
- 国际申请： PCT/US02/37646 WO 20021125
- 国际公布： WO03/045315 WO 20030605
- 主分类号： C07D265/12
- IPC分类号： C07D265/12 ; C07D265/14 ; C07D491/04 ; C07D498/04 ; C07D513/04 ; C07D515/04 ; A61K31/536 ; A61K31/5365 ; A61P25/18
摘要：
This invention related to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed In a variety of dementias, and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson′s disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions and methods of using these compounds for such treatment.