A computer-implemented method for intervertebral disc alignment includes providing a spine image and a click point on the spine image, applying an adaptive thresholding technique to segment vertebrae regions at the click point from the spine image, and filtering segmented vertebrae regions with a morphological operation. The method further includes estimating a multi-scale orientation field from filtered segmented vertebrae regions, extracting an intervertebral disc region by applying region growing for each scale, integrating the multi-scale orientation field in a locally segmented intervertebral disc region based on the intervertebral disc region, estimating a disc centerline from the filtered segmented vertebrae regions, and fusing an integrated multi-scale orientation field with the disc centerline based on associated confidence measures to provide an intervertebral disc alignment.