发明授权
US07807437B2 Variants of hepatitis B virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof
有权
乙型肝炎病毒对某些核苷类似物具有抗性但对其他人敏感的变体及其用途
- 专利标题： Variants of hepatitis B virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof
- 专利标题（中）： 乙型肝炎病毒对某些核苷类似物具有抗性但对其他人敏感的变体及其用途
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申请号： US11375580申请日： 2006-03-15
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公开(公告)号： US07807437B2公开(公告)日： 2010-10-05
- 发明人: Oliver Schildgen , Martin Vogel , Bertfried Matz , Juergen Rockstroh , Rolf Kaiser , Martin Daeumer , Martin Helm , Lutwin Weitner , Carl Knud Schewe , Wolfram Gerlich
- 申请人： Oliver Schildgen , Martin Vogel , Bertfried Matz , Juergen Rockstroh , Rolf Kaiser , Martin Daeumer , Martin Helm , Lutwin Weitner , Carl Knud Schewe , Wolfram Gerlich
- 申请人地址： DE Bonn DE Cologne DE Giessen
- 专利权人： Rheinishche Friedrich-Wilhelms-Universitaet Bonn,Universitaet Zu Koeln,Justus-Liebig-Universitaet Gissen
- 当前专利权人： Rheinishche Friedrich-Wilhelms-Universitaet Bonn,Universitaet Zu Koeln,Justus-Liebig-Universitaet Gissen
- 当前专利权人地址： DE Bonn DE Cologne DE Giessen
- 代理机构： Nixon & Vanderhye P.C.
- 优先权： EP05102014 20050315
- 主分类号： C12N7/00
- IPC分类号： C12N7/00
摘要：
The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues both in vivo and in vitro. More in particular, reverse transcriptase mutant rt I233V is provided. Present invention provides assays and methods for detecting such variant, which assays are useful in monitoring anti-viral therapeutic regimes and adjusting patient therapy. A diagnostic kit for detecting the presence of an HBV variant in a biological sample has also been described. Finally, the use of a pharmaceutical composition to cure a subject suffering from a HBV infection, which HBV is resistant to lamuvidine and/or adefovir has been provided, which pharmaceutical composition comprises the nucleoside analogue tenofovir.
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