发明授权
US07812027B2 Substitued [1,2,4]triazolo[1,5-a]pyrazines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
有权
取代的[1,2,4]三唑并[1,5-a]吡嗪作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病
![Substitued [1,2,4]triazolo[1,5-a]pyrazines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes](/docs/US/2010-10-12/US07812027B2/abs.jpg.600x600.jpg)
- 专利标题： Substitued [1,2,4]triazolo[1,5-a]pyrazines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
- 专利标题（中）： 取代的[1,2,4]三唑并[1,5-a]吡嗪作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病
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申请号： US12226584申请日： 2007-05-11
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公开(公告)号： US07812027B2公开(公告)日： 2010-10-12
- 发明人: Tesfaye Biftu , Ping Chen , Danqing Feng , Ann E. Weber
- 申请人： Tesfaye Biftu , Ping Chen , Danqing Feng , Ann E. Weber
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Janet E. Fair; John C. Todaro
- 国际申请： PCT/US2007/011520 WO 20070511
- 国际公布： WO2007/136603 WO 20071129
- 主分类号： A61K31/50
- IPC分类号： A61K31/50
![Substitued [1,2,4]triazolo[1,5-a]pyrazines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes](/abs-image/US/2010/10/12/US07812027B2/abs.jpg.150x150.jpg)
摘要：
The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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