发明授权
- 专利标题： Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
- 专利标题（中）： 抑制整联蛋白与其受体结合的羧酸衍生物
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申请号： US11152695申请日： 2005-06-14
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公开(公告)号： US07812038B2公开(公告)日： 2010-10-12
- 发明人: Ronald J. Biediger , Qi Chen , E. Radford Decker , George W. Holland , Jamal M. Kassir , Wen Li , Robert V. Market , Ian L. Scott , Chengde Wu , Jian Li
- 申请人： Ronald J. Biediger , Qi Chen , E. Radford Decker , George W. Holland , Jamal M. Kassir , Wen Li , Robert V. Market , Ian L. Scott , Chengde Wu , Jian Li
- 申请人地址： US NY New York
- 专利权人： Encysive Pharmaceuticals, Inc.
- 当前专利权人： Encysive Pharmaceuticals, Inc.
- 当前专利权人地址： US NY New York
- 代理机构： Jones Day
- 主分类号： A61K31/4412
- IPC分类号： A61K31/4412
摘要：
A method for the inhibition of the binding of α4β1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either a above, or in formulations for the control or prevention of diseases states in which α4β1 is involved.
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