发明授权
- 专利标题: RNAi modulation of Aha and therapeutic uses thereof
- 专利标题(中): Aha的RNAi调节及其治疗用途
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申请号: US11750553申请日: 2007-05-18
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公开(公告)号: US07812150B2公开(公告)日: 2010-10-12
- 发明人: Rainer Constien , Birgit Bramlage , Pamela Tan , Hans-Peter Vornlocher , William Balch
- 申请人: Rainer Constien , Birgit Bramlage , Pamela Tan , Hans-Peter Vornlocher , William Balch
- 申请人地址: US MA Cambridge
- 专利权人: Alnylam Pharmaceuticals, Inc.
- 当前专利权人: Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址: US MA Cambridge
- 代理机构: Fenwick & West LLP
- 主分类号: C07H21/04
- IPC分类号: C07H21/04
摘要:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an Aha gene (Aha1 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an Aha gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier, methods for treating diseases caused by Aha1 expression and the expression of an Aha gene using the pharmaceutical composition; and methods for inhibiting the expression of an Aha gene in a cell.
公开/授权文献
- US20080113931A1 RNAi MODULATION OF AHA AND THERAPEUTIC USES THEREOF 公开/授权日:2008-05-15
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