A method of configuring a sub-slot having a layer-modulated multi-user packet (MUP) is disclosed. More specifically, the method comprises modulating symbols associated with a first layer by using non-layered modulation scheme, and modulating symbols associated with a second layer and a third layer using a different layered-modulation scheme. Here, the symbols associated with the second layer and the third layer are multiplexed by any one of an orthogonal frequency division multiplexing, a code division multiplexing, a multi-carrier code division multiplexing, or a time division multiplexing.