发明授权
- 专利标题： Sustained release drug carrier
- 专利标题（中）： 持续释放药物载体
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申请号： US10536031申请日： 2003-11-21
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公开(公告)号： US07816316B2公开(公告)日： 2010-10-19
- 发明人: Sei Kwang Hahn , Teruo Nakamura , Tsuyoshi Shimoboji
- 申请人： Sei Kwang Hahn , Teruo Nakamura , Tsuyoshi Shimoboji
- 申请人地址： JP Tokyo
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo
- 代理机构： Browdy and Neimark, PLLC
- 优先权： JP2002-338167 20021121
- 国际申请： PCT/JP03/14906 WO 20031121
- 国际公布： WO2004/046200 WO 20040603
- 主分类号： A61K38/02
- IPC分类号： A61K38/02 ; A61K31/728
摘要：
The present invention aims to provide completely biodegradable and biocompatible sustained-release carriers for proteins or peptides, which allow encapsulation of the proteins or peptides at high encapsulation rates without inhibiting their biological activity. The present invention provides a method for preparing a sustained-release carrier, wherein in a solution in the presence of a protein or a peptide, a hyaluronic acid derivative having an unsaturated bond(s) or a mercapto group(s) introduced into hyaluronic acid is chemically crosslinked with a mercapto group-containing compound or an unsaturated bond-containing compound, respectively, to give a hydrogel. The method of the present invention enables efficient encapsulation of proteins or peptides while retaining their biological activity.
公开/授权文献
- US20060110458A1 Sustained release drug carrier 公开/授权日：2006-05-25