发明授权
US07816369B2 Mediators of hedgehog signaling pathways, compositions and uses related thereto
有权
刺猬信号通路的调解者，与之相关的组合物和用途
- 专利标题： Mediators of hedgehog signaling pathways, compositions and uses related thereto
- 专利标题（中）： 刺猬信号通路的调解者，与之相关的组合物和用途
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申请号： US11718470申请日： 2005-11-03
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公开(公告)号： US07816369B2公开(公告)日： 2010-10-19
- 发明人: Oivin M. Guicherit , Edward Andrew Boyd , Shirley Ann Brunton , Stephen Price , John Harry Alexander Stibbard , Colin H. MacKinnon
- 申请人： Oivin M. Guicherit , Edward Andrew Boyd , Judith Boyd, legal representative , Shirley Ann Brunton , Stephen Price , John Harry Alexander Stibbard , Colin H. MacKinnon
- 申请人地址： US MA Cambridge US CA South San Francisco
- 专利权人： Curis, Inc.,Genentech, Inc.
- 当前专利权人： Curis, Inc.,Genentech, Inc.
- 当前专利权人地址： US MA Cambridge US CA South San Francisco
- 代理机构： Millen, White, Zelano, Branigan, P.C.
- 国际申请： PCT/US2005/040054 WO 20051103
- 国际公布： WO2006/050506 WO 20060511
- 主分类号： A61K31/4427
- IPC分类号： A61K31/4427 ; C07D471/04 ; C07D413/02 ; C07D401/02
摘要：
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
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