发明授权
US07820212B2 Abietane diterpenoid compound, and composition comprising extract of Torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease 有权
二亚戊基二萜类化合物,以及由它们提取物组成的组合物,其中包括从它们中分离出的Torreya nucifera或二萜烷二萜类化合物或萜类化合物,用于预防和治疗心血管疾病

Abietane diterpenoid compound, and composition comprising extract of Torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease
摘要:
The present invention relates to a method for treating a cardiovascular disease, such as hyperlipidemia or atherosclerosis, with a pharmaceutically effective amount of an extract of Torreya nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. Torreya nucifera extracts, abietane diterpenoid compound, or terpenoid compound isolated from the extracts were prepared by extracting Torreya nucifera leaves, stems, or seeds with water, alcohol, or mixed solution of water and alcohol, which is further fractionized with n-hexane, chloroform and etheyl acetate in that order. Further, the present invention provides a method for inhibiting an oxidation of low-density lipoprotein (LDL) and inhibiting Acyl-CoA:cholesterol acyltransferase (ACAT) using an extract of Torreya nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient.
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