发明授权
US07820212B2 Abietane diterpenoid compound, and composition comprising extract of Torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease
有权
二亚戊基二萜类化合物,以及由它们提取物组成的组合物,其中包括从它们中分离出的Torreya nucifera或二萜烷二萜类化合物或萜类化合物,用于预防和治疗心血管疾病
- 专利标题: Abietane diterpenoid compound, and composition comprising extract of Torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease
- 专利标题(中): 二亚戊基二萜类化合物,以及由它们提取物组成的组合物,其中包括从它们中分离出的Torreya nucifera或二萜烷二萜类化合物或萜类化合物,用于预防和治疗心血管疾病
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申请号: US12181583申请日: 2008-07-29
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公开(公告)号: US07820212B2公开(公告)日: 2010-10-26
- 发明人: Tae-Sook Jeong , Woo-Song Lee , Hyoung-Chin Kim , Yang-Kyu Choi , Ju-Ryoung Kim , So-Jin An , Kyoung-Ran Im , Ki-Chang Jang , Og-Sung Moon , Jun-Seock Son
- 申请人: Tae-Sook Jeong , Woo-Song Lee , Hyoung-Chin Kim , Yang-Kyu Choi , Ju-Ryoung Kim , So-Jin An , Kyoung-Ran Im , Ki-Chang Jang , Og-Sung Moon , Jun-Seock Son
- 申请人地址: KR Taijeon-Si
- 专利权人: Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人: Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人地址: KR Taijeon-Si
- 代理机构: Lucas & Mercanti, LLP
- 优先权: KR10-2004-0014236 20040303; KR10-2004-0089372 20041104; KR10-2004-0112140 20041224
- 主分类号: A61K36/13
- IPC分类号: A61K36/13 ; A61K36/00
摘要:
The present invention relates to a method for treating a cardiovascular disease, such as hyperlipidemia or atherosclerosis, with a pharmaceutically effective amount of an extract of Torreya nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. Torreya nucifera extracts, abietane diterpenoid compound, or terpenoid compound isolated from the extracts were prepared by extracting Torreya nucifera leaves, stems, or seeds with water, alcohol, or mixed solution of water and alcohol, which is further fractionized with n-hexane, chloroform and etheyl acetate in that order. Further, the present invention provides a method for inhibiting an oxidation of low-density lipoprotein (LDL) and inhibiting Acyl-CoA:cholesterol acyltransferase (ACAT) using an extract of Torreya nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient.
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