发明授权
US07820702B2 Sulfonylpyrrolidine modulators of androgen receptor function and method
有权
磺酰吡咯烷酮调节剂的雄激素受体功能及方法
- 专利标题： Sulfonylpyrrolidine modulators of androgen receptor function and method
- 专利标题（中）： 磺酰吡咯烷酮调节剂的雄激素受体功能及方法
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申请号： US11048439申请日： 2005-02-01
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公开(公告)号： US07820702B2公开(公告)日： 2010-10-26
- 发明人: Lawrence G. Hamann , Yingzhi Bi , Mark C. Manfredi , Alexandra A. Nirschl , James C. Sutton
- 申请人： Lawrence G. Hamann , Yingzhi Bi , Mark C. Manfredi , Alexandra A. Nirschl , James C. Sutton
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Burton Rodney
- 主分类号： A61K31/433
- IPC分类号： A61K31/433 ; C07D285/10
摘要：
Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2, R3, R4, R4a, R4b, R4c, R4c1, Rd, Re, Rf, Rg, Rh, R5, R5′, R7, and R7′ are defined herein; G is aryl, heterocycle or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; and n is an integer of 1 or 2, m is an integer of 1 or 2, Z is oxygen (—O—) or NR4b, a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.