A fluid sensing system and method for sensing properties of a flowing fluid. The system and method entail a microfluidic device having a micromachined tube supported above a substrate, a tube passage within a freestanding portion of the tube, an inlet and outlet in fluidic communication with the tube passage and an exterior of the microfluidic device, elements for vibrating the freestanding portion of the tube, and elements for sensing movement of the freestanding portion of the tube so as to measure the vibration frequency and/or deflection of the freestanding portion and produce therefrom at least one output corresponding to a property of a fluid flowing through the tube passage. The system and method further entail placing the microfluidic device in a flowing fluid so that a fraction of the fluid enters the tube passage, and processing the output of the device to compute a property of the fluid.