The present invention relates to methods and systems for selecting and recording biopsy sites in a body tissue or organ. More in particular the present invention provides a method for selecting and recording biopsy sites in a body organ comprising: a) obtaining a three-dimensional volume of backscattered Ultrasound data grid of a three-dimensional region of the organ; b) obtaining a two-dimensional matrix of Ultrasound data of a two-dimensional sub-region of said organ; c) positioning the two-dimensional matrix of Ultrasound data in the three-dimensional volume of backscattered Ultrasound data grid obtained in step (a); d) optionally selecting one or more sites in the two-dimensional matrix of Ultrasound data where a biopsy is to be obtained; e) indicating in the three-dimensional volume of backscattered Ultrasound data grid and/or in the two-dimensional matrix of Ultrasound data any sites at which biopsies were obtained; and f) optionally repeating steps (b) to (e) as required.