An ambidextrous locking clamp system for providing a user the ability to alter the configuration of a hand operated device allowing a right or left handed user to operate the device. The device has a hingedly connected first and second elongated member each with a finger engaging member, a working head, and an indicator for identifying if the clamp is setup for left or right handed operation. At least two inter-engaging latching members are removably attachable to the first and the second elongated members. The latching members are symmetrical, interchangeable, and reversible, allowing a user to change the configuration of the ambidextrous device. The latching members can be retained to the elongated members by a rotatably lever, a removable retaining cap, or a removable retaining pin. Additionally, the latching members can be incorporated into removable finger engaging members, thereby allowing the entire finger engaging member and latching member to be removed, interchanged or reversed.