Invention Grant
US07824491B2 Method for crystallizing aurora 2 kinase catalytic domain polypeptide
有权
用于结晶极光2激酶催化结构域多肽的方法
- Patent Title: Method for crystallizing aurora 2 kinase catalytic domain polypeptide
- Patent Title (中): 用于结晶极光2激酶催化结构域多肽的方法
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Application No.: US12184770Application Date: 2008-08-01
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Publication No.: US07824491B2Publication Date: 2010-11-02
- Inventor: Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
- Applicant: Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
- Applicant Address: US NJ Kenilworth
- Assignee: Schering Corp.
- Current Assignee: Schering Corp.
- Current Assignee Address: US NJ Kenilworth
- Main IPC: C30B28/06
- IPC: C30B28/06 ; G01N31/00 ; C12N9/12
Abstract:
The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human Aurora 2 kinase. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human Aurora 2 kinase in structure assisted drug design to identify compounds that can modulate the enzymatic activity of human Aurora 2 kinase.
Public/Granted literature
- US20090081706A1 CRYSTALLINE FORM OF THE CATALYTIC DOMAIN OF AURORA 2 KINASE AND METHODS OF USE THEREOF Public/Granted day:2009-03-26
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