Invention Grant
US07824684B2 Methods of inhibiting the binding of P-selectin to PSGL-1 with anti-P-selectin antibodies
有权
用抗P-选择蛋白抗体抑制P-选择素与PSGL-1结合的方法
- Patent Title: Methods of inhibiting the binding of P-selectin to PSGL-1 with anti-P-selectin antibodies
- Patent Title (中): 用抗P-选择蛋白抗体抑制P-选择素与PSGL-1结合的方法
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Application No.: US12768150Application Date: 2010-04-27
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Publication No.: US07824684B2Publication Date: 2010-11-02
- Inventor: Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Strein , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
- Applicant: Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Strein , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Dennis P. Tramaloni; Brian C. Remy
- Priority: EP04008722 20040413
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28
Abstract:
This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or peripheral arterial occlusive disease (CLI/PAOD).
Public/Granted literature
- US20100209423A1 METHODS OF INHIBITING THE BINDING OF P-SELECTIN TO PSGL-1 Public/Granted day:2010-08-19
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