Invention Grant
- Patent Title: Delivery of proteins across polar epithelial cell layers
- Patent Title (中): 通过极性上皮细胞层递送蛋白质
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Application No.: US10110880Application Date: 2000-10-18
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Publication No.: US07824695B1Publication Date: 2010-11-02
- Inventor: David J. FitzGerald , Randall J. Mrsny , Marian McKee , Ann Daugherty
- Applicant: David J. FitzGerald , Randall J. Mrsny , Marian McKee , Ann Daugherty
- Applicant Address: US DC Washington US CA South San Francisco
- Assignee: The United States of America as represented by the Department of Health and Human Services,Genentech, Inc.
- Current Assignee: The United States of America as represented by the Department of Health and Human Services,Genentech, Inc.
- Current Assignee Address: US DC Washington US CA South San Francisco
- Agency: Townsend and Townsend and Crew LLP
- International Application: PCT/US00/29080 WO 20001018
- International Announcement: WO01/30392 WO 20010503
- Main IPC: A61K39/108
- IPC: A61K39/108 ; A61K39/38 ; A61K38/00 ; G01N1/00 ; G01N33/554 ; C07K1/00 ; C07H21/02
Abstract:
This invention provides bioactive conjugates. The bioactive conjugates include: (1) a cell recognition moiety that binds to α2 macroglobulin receptor α2-MR and (2) a bioactive moiety which: (a) has a biological activity, (b) does not function solely as an immunogen to invoke an immune response and (c) does not have ADP ribosylating activity. The bioactive conjugates of this invention are useful in methods of transporting the bioactive moiety across a polar epithelial membrane. Thus, this invention provides methods for parenteral administration of proteins without injection.
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