Invention Grant
US07824893B2 In vivo incorporation of alkynyl amino acids into proteins in eubacteria
有权
将炔基氨基酸体内并入真细菌中的蛋白质
- Patent Title: In vivo incorporation of alkynyl amino acids into proteins in eubacteria
- Patent Title (中): 将炔基氨基酸体内并入真细菌中的蛋白质
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Application No.: US11663513Application Date: 2005-09-20
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Publication No.: US07824893B2Publication Date: 2010-11-02
- Inventor: Alexander Deiters , Peter G. Schultz
- Applicant: Alexander Deiters , Peter G. Schultz
- Applicant Address: US CA La Jolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Quine Intellectual Property Law Group
- Agent Gary Baker
- International Application: PCT/US2005/033784 WO 20050920
- International Announcement: WO2006/034332 WO 20060330
- Main IPC: C12P21/04
- IPC: C12P21/04 ; C12N1/20 ; C12N9/00
Abstract:
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate alkynyl amino acids such as para-propargyloxyphenylalanine into proteins produced in a eubacteria host such as E. coli. The invention provides novel orthoghonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing alkynyl amino acids, and cellular translation systems.
Public/Granted literature
- US20080220472A1 In Vivo Incorporation of Alkynyl Amino Acids into Proteins in Eubacteria Public/Granted day:2008-09-11
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