Invention Grant
- Patent Title: Hepatic stellate cell progenitors and methods of isolating same
- Patent Title (中): 肝星状细胞祖细胞及其分离方法
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Application No.: US11753326Application Date: 2007-05-24
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Publication No.: US07824911B2Publication Date: 2010-11-02
- Inventor: Hiroshi Kubota , Lola M. Reid
- Applicant: Hiroshi Kubota , Lola M. Reid
- Applicant Address: US NC Chapel Hill
- Assignee: University of North Carolina at Chapel Hill
- Current Assignee: University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Foley & Lardner LLP
- Agent Gilberto M. Villacorta; Sunit Talapatra
- Main IPC: C12N5/00
- IPC: C12N5/00
Abstract:
The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-1+, VCAM-1+, β3-integrin+. In addition to expression of these surface markers, the cells also express the intracellular markers desmin, vimentin, smooth muscle α-actin, nestin, hepatocyte growth factor, stromal derived factor-1α and H1x homeobox transcriptional factor.
Public/Granted literature
- US20080009057A1 HEPATIC STELLATE CELL PRECURSORS AND METHODS OF ISOLATING SAME Public/Granted day:2008-01-10
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