A formula and method for rapid neutralization of formaldehyde solutions and vapor is provided. The invention comprises a matrix or medium upon which a mixture of urea, acid, calcium chloride and water is applied and dried. When the treated matrix or medium comes into contact with formaldehyde solution or vapor, the hydroscopic nature of the calcium chloride dried on the medium quickly absorbs and neutralizes the formaldehyde, irreversibly changing the formaldehyde molecules to a nonhazardous and nontoxic polymer. This reduces the risk of exposure to formaldehyde solution and vapor by the technician handling the material.