Invention Grant
US07825085B2 Fragments of NKp44 and NKp46 for targeting viral-infected and tumor cells
有权
用于靶向病毒感染和肿瘤细胞的NKp44和NKp46的片段
- Patent Title: Fragments of NKp44 and NKp46 for targeting viral-infected and tumor cells
- Patent Title (中): 用于靶向病毒感染和肿瘤细胞的NKp44和NKp46的片段
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Application No.: US10562735Application Date: 2004-06-30
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Publication No.: US07825085B2Publication Date: 2010-11-02
- Inventor: Ofer Mandelboim , Angel Porgador
- Applicant: Ofer Mandelboim , Angel Porgador
- Applicant Address: IL Jerusalem IL Beer-Sheva
- Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem,Ben-Gurion University of the Negev Research and Development Authority
- Current Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem,Ben-Gurion University of the Negev Research and Development Authority
- Current Assignee Address: IL Jerusalem IL Beer-Sheva
- Agency: Winston & Strawn LLP
- International Application: PCT/IL2004/000583 WO 20040630
- International Announcement: WO2005/000086 WO 20050106
- Main IPC: A61K38/14
- IPC: A61K38/14 ; A61K38/17 ; C07K14/705 ; C07K9/00
Abstract:
The present invention relates generally to peptides derived from the natural cytotoxicity receptors on natural killer (NK) cells and to antibodies against peptide epitopes on these receptors. In particular, the present invention identifies an essential epitope in the proximal domain of NKp46 and NKp44 receptors present on NK cells, as a crucial element for the binding to viral-infected cells. The present invention provides peptides that are derived from the amino acid sequence of NKp46 receptor, capable of specific targeting of viral-infected cells and tumor cells and monoclonal antibodies which recognize a specific domain of NKp46. The present invention further provides hyperglycosylated peptides that are derived from the NKp44 receptor, capable of specific targeting of viral-infected cells.
Public/Granted literature
- US20070203054A1 Fragments of nkp44 for targeting viral-infected and tumor cells Public/Granted day:2007-08-30
Information query
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