Invention Grant
- Patent Title: Nanoparticulate and controlled release compositions comprising cyclosporine
- Patent Title (中): 包含环孢菌素的纳米颗粒和控释组合物
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Application No.: US11568692Application Date: 2006-04-12
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Publication No.: US07825087B2Publication Date: 2010-11-02
- Inventor: Scott A. Jenkins , Gary Liversidge
- Applicant: Scott A. Jenkins , Gary Liversidge
- Applicant Address: IE County Westmeath
- Assignee: Elan Pharma International Limited
- Current Assignee: Elan Pharma International Limited
- Current Assignee Address: IE County Westmeath
- Agency: Fox Rothschild LLP
- International Application: PCT/US2006/013631 WO 20060412
- International Announcement: WO2006/110802 WO 20061019
- Main IPC: A61K38/12
- IPC: A61K38/12 ; A61K51/08
Abstract:
The present invention is directed to a composition comprising a nanoparticulate cyclosporine having improved bioavailability. The nanoparticulate cyclosporine particles of the composition have an effective average particle size of less than about 2000 nm in diameter and are useful in the prevention and treatment of organ transplant rejection and autoimmune diseases such as psoriasis, rheumatoid arthritis, and other related diseases. The invention also relates to a controlled release composition comprising a cyclosporine or a nanoparticulate cyclosporine that in operation delivers the drug in a pulsed or bimodal manner for the prevention and treatment of organ transplant rejection and autoimmune diseases such as psoriasis, rheumatoid arthritis, and other related diseases.
Public/Granted literature
- US20080124389A1 Nanoparticulate and Controlled Release Compositions Comprising Cyclosporine Public/Granted day:2008-05-29
Information query
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